If you have a Xamarin Studio project for an Android application, you'll probably want to use Android Studio to edit the resource files.
- Create a new Android Studio project (I usually call it AndroidStudioHolder, but the name is unimportant)
- cd AndroidStudioHolder/app/src/main
- rm -rf res
- ln -s ../../../../YourAndroidProject/Resources res
Unfortunately, you still have to deal with all the weird naming issues that Xamarin Studio creates. You should fix them anyway, and it's easier to do it early in the project. (Main.axml isn't a real layout file, for example, even though Xamarin Studio will create it for you by default.)